Molecular Formula | C13H19NO3 |
Molar Mass | 237.29 |
Density | 1.154±0.06 g/cm3(Predicted) |
Melting Point | 200-210°C |
Boling Point | 392.4±42.0 °C(Predicted) |
Appearance | neat |
pKa | 8.02±0.31(Predicted) |
HS Code | 2922504500 |
Introduction | salbutamol impurity D is an impurity produced during the synthesis of salbutamol. Salbutamol impurity D not only retains the chemical structure of the parent nucleus of β-agonists to the greatest extent, but also introduces-CHO, which can be coupled with proteins, through chemical synthesis. The synthesis method is simple, the purity and yield were high. |
Application | using salbutamol impurity D as a raw material, an antigen system suitable for animal immunization is prepared to immunize animals, the titer, specificity and Affinity of the obtained antibody are good; The obtained antibody is used in the enzyme-linked immunosorbent assay kit, which can simultaneously detect clenbuterol, salbutamol, sebuterol, tobuterol, bromobuterol, bromoclobuterol six drugs, easy to use, low cost detection. |
preparation | 1.0G salbutamol, dissolved in 20ml N,N-dimethylformamide, then, 10 mol% of tetramethylpiperidine oxide, 10 mol% of tetrabutylammonium chloride and 20ml of 0.5mol/L NaHCO3 aqueous solution were added, and after stirring for 30min at room temperature, add 1.1 molar equivalent of N-chlorosuccinimide, reaction at room temperature after 2~5H, remove most of the solvent, ethyl acetate extraction, washing, drying, remove the solvent column chromatography purification, A white solid salbutamol monooxide, I .e., Salbutamol impurity D, was obtained. |